nor-Binaltorphimine (Synonyms: Norbinaltorphimine; NorBNI)

Name: nor-Binaltorphimine
Brand: MedChemExpress
SKU: HY-117040
Rating: 5.0 (4 reviews)

Cat. No.: HY-117040 Purity: 98.20%: FAQs
Data Sheet SDS COA Handling Instructions

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nor-Binaltorphimine is a selective antagonist of kappa-opioid receptor. nor-Binaltorphimine has a long-lasting effect in vivo.

For research use only. We do not sell to patients.

nor-Binaltorphimine Chemical Structure

CAS No. : 105618-26-6

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 380	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of nor-Binaltorphimine:

Norbinaltorphimine dihydrochloride Get quote

4 Publications Citing Use of MCE nor-Binaltorphimine

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•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

nor-Binaltorphimine is a selective antagonist of kappa-opioid receptor. nor-Binaltorphimine has a long-lasting effect in vivo^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.28 nM Compound: norBNI	Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assay	[PMID: 25593096]
CHO	EC₅₀	120 nM Compound: 1, norBNI	Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 20568781]
CHO	IC₅₀	2.9 nM Compound: norBNI	Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis	[PMID: 27556704]
CHO	EC₅₀	380 nM Compound: 1, norBNI	Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 20568781]
CHO	IC₅₀	4.6 nM Compound: norBNI	Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK phosphorylation pre-incubated with compound before U69,593 stimulation for 10 mins Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK phosphorylation pre-incubated with compound before U69,593 stimulation for 10 mins	[PMID: 25593096]
CHO	EC₅₀	6 nM Compound: 1, norBNI	Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 20568781]
U2OS	IC₅₀	2.5 nM Compound: norBNI	Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69,593 stimulation for 90 mins by DiscoveRx beta-arrestin2 recruitment based PathHunter assay Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69,593 stimulation for 90 mins by DiscoveRx beta-arrestin2 recruitment based PathHunter assay	[PMID: 25593096]

Molecular Weight

661.79

Formula

C₄₀H₄₃N₃O₆

CAS No.

105618-26-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@]12[C@]34[C@](OC5=C(O)C=CC(C[C@@]2([H])N(CC4)CC6CC6)=C53)([H])C7=C(C8=C([C@@]9([H])[C@]%10%11[C@@](C8)([C@](CC%12=C%11C(O9)=C(C=C%12)O)([H])N(CC%10)CC%13CC%13)O)N7)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 33.08 mg/mL (49.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5111 mL	7.5553 mL	15.1105 mL
5 mM	0.3022 mL	1.5111 mL	3.0221 mL
10 mM	0.1511 mL	0.7555 mL	1.5111 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.20%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (264 KB)

Handling Instructions (2659 KB)

References

[1]. Spanagel R, et al. Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes. Eur J Pharmacol. 1994 Oct 24;264(2):157-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5111 mL	7.5553 mL	15.1105 mL	37.7763 mL
	5 mM	0.3022 mL	1.5111 mL	3.0221 mL	7.5553 mL
	10 mM	0.1511 mL	0.7555 mL	1.5111 mL	3.7776 mL
	15 mM	0.1007 mL	0.5037 mL	1.0074 mL	2.5184 mL
	20 mM	0.0756 mL	0.3778 mL	0.7555 mL	1.8888 mL
	25 mM	0.0604 mL	0.3022 mL	0.6044 mL	1.5111 mL
	30 mM	0.0504 mL	0.2518 mL	0.5037 mL	1.2592 mL
	40 mM	0.0378 mL	0.1889 mL	0.3778 mL	0.9444 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

nor-Binaltorphimine Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nor-Binaltorphimine105618-26-6Norbinaltorphimine NorBNIOpioid Receptorkappa-opioid receptorAntinociceptionInhibitorinhibitorinhibit

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nor-Binaltorphimine (Synonyms: Norbinaltorphimine; NorBNI)

Customer Review

Other Forms of nor-Binaltorphimine:

nor-Binaltorphimine Related Antibodies

4 Publications Citing Use of MCE nor-Binaltorphimine

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

nor-Binaltorphimine Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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