2. Natural Products
  3. Plants Alkaloids
  4. Saururaceae Piperidine Alkaloids
  5.  Houttuynia cordata Thunb.
  6. Norcepharadione B

Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED50s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively.

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Norcepharadione B Chemical Structure

Norcepharadione B Chemical Structure

CAS No. : 57576-41-7

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Norcepharadione B Related Antibodies

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Description

Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED50s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively[1].

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
37 μM
Compound: 14
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
[PMID: 33822610]
Molecular Weight

307.30

Formula

C18H13NO4
CAS No.
SMILES

COC1=C(OC)C=C(C2=O)C3=C1C(C=CC=C4)=C4C=C3NC2=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Norcepharadione B Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norcepharadione B57576-41-7OthersHouttuynia cordataCytotoxicityAlkaloidA-549SK-OV-3SK-MEL-2XF-498HCT-15Inhibitorinhibitorinhibit

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