Norfenfluramine (Synonyms: (±)-Norfenfluramine)

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Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo.

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Norfenfluramine Chemical Structure

CAS No. : 1886-26-6

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Other Forms of Norfenfluramine:

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Description	Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo^[1]^[2].
In Vitro	(±)-Norfenfluramine interacts with 5-hydroxytryptamine (5-HT) transporters to release 5-HT from neurons^[1]. (±)-Norfenfluramine increases [³H]dopamine and [³H] norepinephrine release in vitro^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Norfenfluramine Related Antibodies
Molecular Weight	203.20
Formula	C₁₀H₁₂F₃N
CAS No.	1886-26-6
SMILES	NC(CC1=CC=CC(C(F)(F)F)=C1)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. [Content Brief] [2]. Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. [Content Brief]

Norfenfluramine Related Classifications

Neurological Disease

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norfenfluramine1886-26-6(±)-NorfenfluramineSerotonin Transporter5-HTTSERTSLC6A4Fenfluramine5-HTtransporterantiepilepticInhibitorinhibitorinhibit

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