NRP1 antagonist 1

Cat. No.: HY-133034 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

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NRP1 antagonist 1 (compound 12a) is a potent NRP1 antagonist with an IC₅₀ of 19.1 μM. NRP1 antagonist 1 has the potential for cancer research.

For research use only. We do not sell to patients.

NRP1 antagonist 1 Chemical Structure

CAS No. : 2569598-01-0

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 710	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

NRP1 antagonist 1 (compound 12a) is a potent NRP1 antagonist with an IC₅₀ of 19.1 μM. NRP1 antagonist 1 has the potential for cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	19.1 μM Compound: 12a	Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrat	[PMID: 31744780]

Molecular Weight

450.58

Formula

C₂₂H₂₂N₆OS₂

CAS No.

2569598-01-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NN=C(CC)S1)CSC2=NN=C(C3=CC=C(C)C=C3)N2C4=CC=CC(C)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (184.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2194 mL	11.0968 mL	22.1936 mL
5 mM	0.4439 mL	2.2194 mL	4.4387 mL
10 mM	0.2219 mL	1.1097 mL	2.2194 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (254 KB) HNMR (276 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Kewen Peng, et al. Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification. Bioorg Med Chem. 2020 Jan 1;28(1):115183. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2194 mL	11.0968 mL	22.1936 mL	55.4840 mL
	5 mM	0.4439 mL	2.2194 mL	4.4387 mL	11.0968 mL
	10 mM	0.2219 mL	1.1097 mL	2.2194 mL	5.5484 mL
	15 mM	0.1480 mL	0.7398 mL	1.4796 mL	3.6989 mL
	20 mM	0.1110 mL	0.5548 mL	1.1097 mL	2.7742 mL
	25 mM	0.0888 mL	0.4439 mL	0.8877 mL	2.2194 mL
	30 mM	0.0740 mL	0.3699 mL	0.7398 mL	1.8495 mL
	40 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3871 mL
	50 mM	0.0444 mL	0.2219 mL	0.4439 mL	1.1097 mL
	60 mM	0.0370 mL	0.1849 mL	0.3699 mL	0.9247 mL
	80 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6936 mL
	100 mM	0.0222 mL	0.1110 mL	0.2219 mL	0.5548 mL