2. Immunology/Inflammation
  3. Complement System
  4. NRP1 antagonist 1

NRP1 antagonist 1 (compound 12a) is a potent NRP1 antagonist with an IC50 of 19.1 μM. NRP1 antagonist 1 has the potential for cancer research.

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NRP1 antagonist 1 Chemical Structure

NRP1 antagonist 1 Chemical Structure

CAS No. : 2569598-01-0

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Description

NRP1 antagonist 1 (compound 12a) is a potent NRP1 antagonist with an IC50 of 19.1 μM. NRP1 antagonist 1 has the potential for cancer research[1].

Molecular Weight

450.58

Formula

C22H22N6OS2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NN=C(CC)S1)CSC2=NN=C(C3=CC=C(C)C=C3)N2C4=CC=CC(C)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (184.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2194 mL 11.0968 mL 22.1936 mL
5 mM 0.4439 mL 2.2194 mL 4.4387 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2194 mL 11.0968 mL 22.1936 mL 55.4840 mL
5 mM 0.4439 mL 2.2194 mL 4.4387 mL 11.0968 mL
10 mM 0.2219 mL 1.1097 mL 2.2194 mL 5.5484 mL
15 mM 0.1480 mL 0.7398 mL 1.4796 mL 3.6989 mL
20 mM 0.1110 mL 0.5548 mL 1.1097 mL 2.7742 mL
25 mM 0.0888 mL 0.4439 mL 0.8877 mL 2.2194 mL
30 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8495 mL
40 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3871 mL
50 mM 0.0444 mL 0.2219 mL 0.4439 mL 1.1097 mL
60 mM 0.0370 mL 0.1849 mL 0.3699 mL 0.9247 mL
80 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
100 mM 0.0222 mL 0.1110 mL 0.2219 mL 0.5548 mL
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NRP1 antagonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NRP1 antagonist 12569598-01-0Complement SystemNRP1cancerInhibitorinhibitorinhibit

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