2. Stem Cell/Wnt
  3. Wnt
  4. NSC668036

NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction.

For research use only. We do not sell to patients.

NSC668036 Chemical Structure

NSC668036 Chemical Structure

CAS No. : 144678-63-7

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5 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

NSC668036 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NSC668036

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].

In Vitro

In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A[1].
NSC668036 (10 μM) suppresses β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of collagen I and α-smooth muscle actin (α-SMA) in fibroblasts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC668036 Related Antibodies
In Vivo

In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

460.52

Formula

C21H36N2O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(OC(C(C)C)C(NC(C)C(OC(C(C)C)C(O)=O)=O)=O)=O)NC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (54.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 5 mg/mL (10.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1715 mL 10.8573 mL 21.7146 mL
5 mM 0.4343 mL 2.1715 mL 4.3429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.1715 mL 10.8573 mL 21.7146 mL 54.2865 mL
5 mM 0.4343 mL 2.1715 mL 4.3429 mL 10.8573 mL
10 mM 0.2171 mL 1.0857 mL 2.1715 mL 5.4286 mL
DMSO 15 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
20 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7143 mL
25 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1715 mL
30 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
40 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
50 mM 0.0434 mL 0.2171 mL 0.4343 mL 1.0857 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NSC668036 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC668036144678-63-7NSC 668036NSC-668036WntDishevelledPDZFrizzledWnt signalingInhibitorinhibitorinhibit

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