2. Immunology/Inflammation
  3. NO Synthase
  4. Nω-Propyl-L-arginine

Nω-Propyl-L-arginine  (Synonyms: N-omega-Propyl-L-arginine)

Cat. No.: HY-102062 Purity: 98.62%
COA Handling Instructions

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Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).

For research use only. We do not sell to patients.

Nω-Propyl-L-arginine Chemical Structure

Nω-Propyl-L-arginine Chemical Structure

CAS No. : 137361-05-8

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5 mg USD 52 In-stock
10 mg USD 98 In-stock
25 mg USD 230 In-stock
50 mg USD 410 In-stock
100 mg USD 730 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Nω-Propyl-L-arginine:

Nω-Propyl-L-arginine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nω-Propyl-L-arginine

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nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].

In Vivo

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2]
Dosage: 20 mg/kg
Administration: I.p.
Result: Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
Molecular Weight

216.28

Formula

C9H20N4O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

N=C(NCCC)NCCC[C@H](N)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (462.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6236 mL 23.1182 mL 46.2364 mL
5 mM 0.9247 mL 4.6236 mL 9.2473 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.62%

COA (243 KB) HNMR (142 KB) LCMS (107 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6236 mL 23.1182 mL 46.2364 mL 115.5909 mL
5 mM 0.9247 mL 4.6236 mL 9.2473 mL 23.1182 mL
10 mM 0.4624 mL 2.3118 mL 4.6236 mL 11.5591 mL
15 mM 0.3082 mL 1.5412 mL 3.0824 mL 7.7061 mL
20 mM 0.2312 mL 1.1559 mL 2.3118 mL 5.7795 mL
25 mM 0.1849 mL 0.9247 mL 1.8495 mL 4.6236 mL
30 mM 0.1541 mL 0.7706 mL 1.5412 mL 3.8530 mL
40 mM 0.1156 mL 0.5780 mL 1.1559 mL 2.8898 mL
50 mM 0.0925 mL 0.4624 mL 0.9247 mL 2.3118 mL
60 mM 0.0771 mL 0.3853 mL 0.7706 mL 1.9265 mL
80 mM 0.0578 mL 0.2890 mL 0.5780 mL 1.4449 mL
100 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1559 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nω-Propyl-L-arginine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nω-Propyl-L-arginine137361-05-8N-omega-Propyl-L-arginineNO SynthaseNitric oxide synthasesNOSlocomotoractivityeNOSstimulatoryantipsychoticpsychotomimeticInhibitorinhibitorinhibit

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