2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. HIF/HIF Prolyl-Hydroxylase HSP
  4. O-Carboranylphenoxyacetanilide

O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC50: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity.

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O-Carboranylphenoxyacetanilide Chemical Structure

O-Carboranylphenoxyacetanilide Chemical Structure

CAS No. : 2260545-92-2

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O-Carboranylphenoxyacetanilide Related Antibodies

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Description

O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC50: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity[1].

IC50 & Target[1]

HIF-1α

 

Molecular Weight

429.29

Formula

C16H24B11NO5
CAS No.
SMILES

O=C(NC1=C(O)C=CC(B(O)O)=C1)COC2=CC=C([C]3456[BH]789[BH]3%10%11[BH]4%12%13[BH]5%14%15[BH]67%16[BH]8%17%18[BH]9%10%19[CH]%12%11%20[BH]%14%13%21[BH]%15%16%17[BH]%18%19%21%20)C=C2
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O-Carboranylphenoxyacetanilide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Carboranylphenoxyacetanilide2260545-92-2HIF/HIF Prolyl-HydroxylaseHSPHypoxia-inducible factorsHIFsHIF-PHHeat shock proteinsHSP60HIF-1αInhibitorinhibitorinhibit

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