O-Carboranylphenoxyacetanilide 

O-Carboranylphenoxyacetanilide is a HIF-1α inhibitor and inhibits HIF-1α activation. O-Carboranylphenoxyacetanilide inhibits transcriptional activity of HIF in HeLa cells (IC₅₀: 0.74 μM). O-Carboranylphenoxyacetanilide inhibits HSP60 chaperone activity and HSP60 ATPase activity^[1].

429.29

C₁₆H₂₄B₁₁NO₅

1220716-15-3

O=C(NC1=C(O)C=CC(B(O)O)=C1)COC2=CC=C([C]3456[BH]789[BH]3%10%11[BH]4%12%13[BH]5%14%15C67%16([H])[BH]8%17%18[BH]9%10%19[BH]%12%11%20[BH]%14%13%21[BH]%15%16%17[BH]%18%19%21%20)C=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ban HS, et al. Identification of HSP60 as a primary target of o-carboranylphenoxyacetanilide, an HIF-1alpha inhibitor. J Am Chem Soc. 2010 Sep 1;132(34):11870-1.  [Content Brief]