2. Epigenetics TGF-beta/Smad
  3. PKC
  4. O-Desmethyl Midostaurin

O-Desmethyl Midostaurin  (Synonyms: CGP62221; O-Desmethyl PKC412)

Cat. No.: HY-129491
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O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

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O-Desmethyl Midostaurin Chemical Structure

O-Desmethyl Midostaurin Chemical Structure

CAS No. : 740816-86-8

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Based on 1 publication(s) in Google Scholar

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O-Desmethyl Midostaurin Related Antibodies

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Description

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

IC50 & Target

IC50: active metabolite of Midostaurin[1]
Molecular Weight

556.61

Formula

C34H28N4O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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O-Desmethyl Midostaurin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-Desmethyl Midostaurin740816-86-8CGP62221 O-Desmethyl PKC412CGP 62221CGP-62221PKCProtein kinase CactivemetabolitePKC412indicatorInhibitorinhibitorinhibit

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