OAB-14

Cat. No.: HY-139973 Purity: 98.72%: FAQs
Data Sheet SDS COA Handling Instructions

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OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice.

For research use only. We do not sell to patients.

OAB-14 Chemical Structure

CAS No. : 2140911-49-3

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 385	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO	USD 385	Ask For Quote & Lead Time
Solid
5 mg	USD 350	Ask For Quote & Lead Time
10 mg	USD 600	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

In Vivo

OAB-14 significantly alleviates cognitive impairments in amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mice after administration for 15 days or 3 months. OAB-14 rapidly cleared 71% of Aβ by promoting microglia phagocytosis and increasing IDE and NEP expression. OAB-14 also attenuates the downstream pathological events of Aβ accumulation, such as synaptic degeneration, neuronal loss, tau hyperphosphorylation and neuroinflammation in APP/PS1 mice. OAB-14 has no significant effect on body weight or liver toxicity after acute and chronic treatment^[1].
OAB-14 facilitates receptor-mediated endocytosis and restores autophagy flux via the AMPK/mTOR pathway. OAB-14 enhances the lysosomal activity, and reduced Aβ accumulation in lysosomes is observed in OAB-14-treated AD mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

518.73

Formula

C₃₂H₄₆N₄O₂

CAS No.

2140911-49-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN)NC1=CC=C(C(NC2=C(C(C)(CCC3(C)C)C)C3=CC4=C2C(C)(C)CCC4(C)C)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (38.56 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9278 mL	9.6389 mL	19.2779 mL
5 mM	0.3856 mL	1.9278 mL	3.8556 mL
10 mM	0.1928 mL	0.9639 mL	1.9278 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.72%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (246 KB) HNMR (265 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Guo X, et al. OAB-14 Effectively Ameliorates the Dysfunction of the Endosomal-Autophagic-Lysosomal Pathway in APP/PS1 Transgenic Mice. ACS Chem Neurosci. 2021;12(21):3985-3993. [Content Brief]

[2]. Yuan C, et al. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. Biochim Biophys Acta Mol Basis Dis. 2019;1865(1):161-180. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9278 mL	9.6389 mL	19.2779 mL	48.1946 mL
	5 mM	0.3856 mL	1.9278 mL	3.8556 mL	9.6389 mL
	10 mM	0.1928 mL	0.9639 mL	1.9278 mL	4.8195 mL
	15 mM	0.1285 mL	0.6426 mL	1.2852 mL	3.2130 mL
	20 mM	0.0964 mL	0.4819 mL	0.9639 mL	2.4097 mL
	25 mM	0.0771 mL	0.3856 mL	0.7711 mL	1.9278 mL
	30 mM	0.0643 mL	0.3213 mL	0.6426 mL	1.6065 mL

OAB-14 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OAB-142140911-49-3OAB14OAB 14Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s diseasecognitiveamyloid-βclearanceendosomal-autophagic-lysosomalmemory impairmentInhibitorinhibitorinhibit

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