2. Membrane Transporter/Ion Channel
  3. OAT
  4. OAT1/3-IN-2

OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage.

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OAT1/3-IN-2 Chemical Structure

OAT1/3-IN-2 Chemical Structure

CAS No. : 2195434-05-8

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Description

OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage[1].

IC50 & Target

Organic anion transporter 1 and 3 (OAT1 and OAT3)[1]
Molecular Weight

328.32

Formula

C18H16O6
CAS No.
SMILES

O=C1C2=CC=C(C(OC)=C2C(C3=C1C=C(C)C(O)=C3OC)=O)OC
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OAT1/3-IN-2 Related Classifications

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Keywords:

OAT1/3-IN-22195434-05-8OATOrganic anion transporterdrug-drug interactionmercury-induced kidney toxicitynatural productorganic anion transporterHEK-OAT1Inhibitorinhibitorinhibit

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