2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Octoclothepin maleate salt

Octoclothepin maleate salt  (Synonyms: Clorotepine maleate salt)

Cat. No.: HY-106587A Purity: 99.14%
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Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents.

For research use only. We do not sell to patients.

Octoclothepin maleate salt Chemical Structure

Octoclothepin maleate salt Chemical Structure

CAS No. : 4789-68-8

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Based on 1 publication(s) in Google Scholar

Octoclothepin maleate salt Related Antibodies

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Description

Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
73.8 μM
Compound: 6
Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay
Inhibition of human TASK3 expressed in HEK293 cells by Ti+ flux assay
[PMID: 31260312]
In Vivo

Octoclothepin possesses high cataleptogenic and anti-apomorphine activities in rats; it is able to exert full protection against apomorphine-induced emesis in dogs after the dose of 0.1 mg/kg s.c.[1].
Octoclothepin in doses of 0.5 and 1.5 mg/kg s.c. reduces the DA level and raises the HVA and DOPAC levels significantly[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

460.97

Formula

C23H25ClN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1693 mL 10.8467 mL 21.6934 mL
5 mM 0.4339 mL 2.1693 mL 4.3387 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.14%

SDS (419 KB)

COA (255 KB) RP-HPLC (242 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1693 mL 10.8467 mL 21.6934 mL 54.2335 mL
5 mM 0.4339 mL 2.1693 mL 4.3387 mL 10.8467 mL
10 mM 0.2169 mL 1.0847 mL 2.1693 mL 5.4233 mL
15 mM 0.1446 mL 0.7231 mL 1.4462 mL 3.6156 mL
20 mM 0.1085 mL 0.5423 mL 1.0847 mL 2.7117 mL
25 mM 0.0868 mL 0.4339 mL 0.8677 mL 2.1693 mL
30 mM 0.0723 mL 0.3616 mL 0.7231 mL 1.8078 mL
40 mM 0.0542 mL 0.2712 mL 0.5423 mL 1.3558 mL
50 mM 0.0434 mL 0.2169 mL 0.4339 mL 1.0847 mL
60 mM 0.0362 mL 0.1808 mL 0.3616 mL 0.9039 mL
80 mM 0.0271 mL 0.1356 mL 0.2712 mL 0.6779 mL
100 mM 0.0217 mL 0.1085 mL 0.2169 mL 0.5423 mL
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Octoclothepin maleate salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octoclothepin4789-68-8ClorotepineDopamine ReceptorneurolepticSR-2AD2DRdepressantInhibitorinhibitorinhibit

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