ODN 2336

Cat. No.: HY-150742: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ODN 2336 is a A-Class CpG ODN (oligodeoxynucleotides), is a potent TLR9 agonist. ODN 2336 induces the production of IFN-α. ODN 2336 up-regulates the expression of IP-10 mRNA and IL-18 mRNA. ODN 2336 can be used as adjuvant of vaccines.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (ODN 2336 sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DNA, d(G-sp-G-sp-G-G-A-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G-sp-G-sp-G)

ODN 2336 Chemical Structure

CAS No. : 332956-64-6

Size	Price	Stock
1 mg	USD 92	Ask For Quote & Lead Time
5 mg	USD 239	Ask For Quote & Lead Time
10 mg	USD 363	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of ODN 2336:

ODN 2336 sodium Get quote
ODN 2336 triethylamine Get quote

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

ODN 2336 (0.5 µM; 24, 48 h) up-regulates the expression of f CD69 and IFN-α^[1].
ODN 2336 (3 µg/ml; 4 h) stimulates strang transcription of IP-10 mRNA after 4 h in human PBMC^[1].
ODN 2336 (3 µg/ml; 2, 4, 16 h) up-regulates the expression of IL-18 mRNA at the 16 htime point^[1].
ODN 2336 (50 μg/mL; 20 h) with IL-3 (10 ng/mL) induces the production of IFN-α in the plasma of adult and cord blood^[2].
ODN 2336 (0.3125-5 µg/ml; 24 h) increases the production of FNA1 in a dose-dependent manner in human PBMCs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

6761.70

CAS No.

332956-64-6

Appearance

Solid

Color

Off-white to light yellow

Sequence

DNA, d(G-sp-G-sp-G-G-A-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G-sp-G-sp-G)

SMILES

[DNA, d(G-sp-G-sp-G-G-A-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G-sp-G-sp-G)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (2.96 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.1479 mL	0.7395 mL	1.4789 mL
5 mM	---	---	---
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 90.74%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (239 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. urk M, et al. C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level. Immunobiology. 2004;209(1-2):141-54. [Content Brief]

[2]. old MC, et al. Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation. Pediatr Res. 2006 Jul;60(1):34-7. [Content Brief]

[3]. Hilbert T, et al. Beta2-adrenoceptor stimulation suppresses TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells. PLoS One. 2013 May 28;8(5):e65024. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O

1 mM

0.1479 mL

0.7395 mL

1.4789 mL

3.6973 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

ODN 2336 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ODN 2336332956-64-6ODN2336ODN-2336Toll-like Receptor (TLR)IFN-αIP-10 mRNAIL-18 mRNAadjuvanthuman PBMCInhibitorinhibitorinhibit

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