ODN MT01 

ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

ODN MT01 can stimulate the proliferation of BMSCs, the differentiation of BMSCs to osteoblasts and mRNA expression of bone-associated factors including Runx2, Osterix, OPG, RANKL and collagen I in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ODN MT01 prevents the loss of alveolar bone in the rats with periodontitis and induced the production of proteins of OPG and Osterix in the bone tissue^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1817821-77-4

DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)

[ODN MT01]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang Q, Qu X, Liang C, et al. Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration. Front Bioeng Biotechnol. 2023;11:1204571.  [Content Brief]

  [2]. Shen Y, Feng Z, Lin C, et al. An oligodeoxynucleotide that induces differentiation of bone marrow mesenchymal stem cells to osteoblasts in vitro and reduces alveolar bone loss in rats with periodontitis. Int J Mol Sci. 2012;13(3):2877-2892.  [Content Brief]

  [3]. Zheng Y., Lin C., Hou X., Ma N., Yu W., Xu X., et al. (2017). Enhancing the osteogenic capacity of MG63 cells through N-isopropylacrylamide-modified polyethylenimine-mediated oligodeoxynucleotide MT01 delivery. RSC Adv. 7, 27121–27127. 10.1039/c6ra27182k