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  3. ODN MT01

ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

For research use only. We do not sell to patients.

DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)

ODN MT01 Chemical Structure

CAS No. : 1817821-77-4

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Description

ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

In Vitro

ODN MT01 can stimulate the proliferation of BMSCs, the differentiation of BMSCs to osteoblasts and mRNA expression of bone-associated factors including Runx2, Osterix, OPG, RANKL and collagen I in vitro[2].

ODN MT01 nanocomplexes affected the cell cycle and promoted cell proliferation of MG63 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ODN MT01 prevents the loss of alveolar bone in the rats with periodontitis and induced the production of proteins of OPG and Osterix in the bone tissue[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
Sequence

DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)

SMILES

[ODN MT01]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ODN MT01
Cat. No.:
HY-150214
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