2. Others Cell Cycle/DNA Damage Epigenetics Autophagy
  3. Isotope-Labeled Compounds PARP Autophagy Mitophagy
  4. Olaparib-d4-1

Olaparib-d4-1  (Synonyms: AZD2281-d4-1; KU0059436-d4-1)

Cat. No.: HY-10162S3 Purity: 98.59%
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Olaparib-d4-1 is the deuterium labeled Olaparib. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

For research use only. We do not sell to patients.

Olaparib-d<sub>4</sub>-1 Chemical Structure

Olaparib-d4-1 Chemical Structure

CAS No. : 2143107-55-3

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1 mg USD 450 In-stock
5 mg USD 1580 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Olaparib-d4-1:

Olaparib-d4-1 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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  • Purity & Documentation

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Description

Olaparib-d4-1 is the deuterium labeled Olaparib. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olaparib-d4-1 Related Antibodies
Molecular Weight

438.49

Formula

C24H19D4FN4O3
CAS No.
Unlabeled CAS

763113-22-0
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC1)C(C2=C(C=CC(CC(C3=C4C=CC=C3)=NNC4=O)=C2)F)=O)C5C([2H])(C5([2H])[2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (228.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 50 mg/mL (114.03 mM; Need ultrasonic)

DMF : 50 mg/mL (114.03 mM; Need ultrasonic)

Ethanol : 3.12 mg/mL (7.12 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 3.12 mg/mL (7.12 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2806 mL 11.4028 mL 22.8055 mL
5 mM 0.4561 mL 2.2806 mL 4.5611 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol / DMF / DMF / DMSO 1 mM 2.2806 mL 11.4028 mL 22.8055 mL 57.0138 mL
5 mM 0.4561 mL 2.2806 mL 4.5611 mL 11.4028 mL
DMF / DMF / DMSO 10 mM 0.2281 mL 1.1403 mL 2.2806 mL 5.7014 mL
15 mM 0.1520 mL 0.7602 mL 1.5204 mL 3.8009 mL
20 mM 0.1140 mL 0.5701 mL 1.1403 mL 2.8507 mL
25 mM 0.0912 mL 0.4561 mL 0.9122 mL 2.2806 mL
30 mM 0.0760 mL 0.3801 mL 0.7602 mL 1.9005 mL
40 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
50 mM 0.0456 mL 0.2281 mL 0.4561 mL 1.1403 mL
60 mM 0.0380 mL 0.1900 mL 0.3801 mL 0.9502 mL
80 mM 0.0285 mL 0.1425 mL 0.2851 mL 0.7127 mL
100 mM 0.0228 mL 0.1140 mL 0.2281 mL 0.5701 mL
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Olaparib-d4-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olaparib-d4-12143107-55-3AZD2281-d4-1KU0059436-d4-1Isotope-Labeled CompoundsPARPAutophagyMitophagypoly ADP ribose polymerase Mitochondrial AutophagyInhibitorinhibitorinhibit

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