OM99-2

Cat. No.: HY-P2713: FAQs
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OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM. OM99-2 is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.

For research use only. We do not sell to patients.

OM99-2 Chemical Structure

CAS No. : 314266-76-7

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Other Forms of OM99-2:

OM99-2 TFA Get quote

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BACE1 BACE2

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Description

OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a K_i value of 9.58 nM^[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor^[2]. OM99-2 has the potential for the research of the Alzheimer's disease^[3].

IC₅₀ & Target

BACE1

In Vitro

Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

892.99

Formula

C₄₁H₆₄N₈O₁₄

CAS No.

314266-76-7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [Content Brief]

[2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [Content Brief]

[3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [Content Brief]

[4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. [Content Brief]

OM99-2 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OM99-2314266-76-7Beta-secretaseBACEβ-SecretaseresiduepeptidomimeticBACE1ADInhibitorinhibitorinhibit

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