2. Membrane Transporter/Ion Channel Autophagy Anti-infection Metabolic Enzyme/Protease
  3. Proton Pump Autophagy Bacterial Phospholipase
  4. Omeprazole-13C,d3

Omeprazole-13C,d3  (Synonyms: H 16868-13C,d3)

Cat. No.: HY-B0113S3 Purity: 98.00%
COA Handling Instructions

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Omeprazole-13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

For research use only. We do not sell to patients.

Omeprazole-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Omeprazole-13C,d3 Chemical Structure

CAS No. : 1261395-28-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Omeprazole-13C,d3:

Omeprazole-13C,d3 Related Antibodies

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Description

Omeprazole-13C,d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Omeprazole-13C,d3 Related Antibodies
Molecular Weight

349.43

Formula

C1613CH16D3N3O3S
CAS No.
Unlabeled CAS

73590-58-6
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C(OC)=C(C=N1)C)=C1CS(C(NC2=C3)=NC2=CC=C3O[13C]([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8618 mL 14.3090 mL 28.6180 mL
5 mM 0.5724 mL 2.8618 mL 5.7236 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8618 mL 14.3090 mL 28.6180 mL 71.5451 mL
5 mM 0.5724 mL 2.8618 mL 5.7236 mL 14.3090 mL
10 mM 0.2862 mL 1.4309 mL 2.8618 mL 7.1545 mL
15 mM 0.1908 mL 0.9539 mL 1.9079 mL 4.7697 mL
20 mM 0.1431 mL 0.7155 mL 1.4309 mL 3.5773 mL
25 mM 0.1145 mL 0.5724 mL 1.1447 mL 2.8618 mL
30 mM 0.0954 mL 0.4770 mL 0.9539 mL 2.3848 mL
40 mM 0.0715 mL 0.3577 mL 0.7155 mL 1.7886 mL
50 mM 0.0572 mL 0.2862 mL 0.5724 mL 1.4309 mL
60 mM 0.0477 mL 0.2385 mL 0.4770 mL 1.1924 mL
80 mM 0.0358 mL 0.1789 mL 0.3577 mL 0.8943 mL
100 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.7155 mL
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Omeprazole-13C,d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Omeprazole-13C,d31261395-28-1H 16868-13C,d3Proton PumpAutophagyBacterialPhospholipaseInhibitorinhibitorinhibit

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