2. Apoptosis
  3. TNF Receptor
  4. Onfekafusp alfa

Onfekafusp alfa  (Synonyms: L19TNF)

Cat. No.: HY-P99772

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Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research.

For research use only. We do not sell to patients.

CAS No. : 1957239-88-1

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Onfekafusp alfa Related Antibodies

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research[1][2].

Isotype

[scFv-heavy-kappa]-trimer
Species

Human
In Vitro

Onfekafusp alfa shows a greater anticancer activity than both mTNFα and TN11mTNFα[2].
Onfekafusp alfa shows a 5 to 6 times higher activity than equimolar amounts of recombinant mTNFα and of the fusion protein TN11mTNFα in cytotoxic assay on L-M mouse fibroblasts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Onfekafusp alfa Related Antibodies
Clinical Trial
CAS No.
SMILES

[Onfekafusp alfa]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [scFv-heavy-kappa]-trimer
Purity & Documentation
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Onfekafusp alfa Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Onfekafusp alfa1957239-88-1L19TNFTNF ReceptorTumor Necrosis Factor ReceptorTNFRFibroblastshomodimermalignant gliomaanticancerInhibitorinhibitorinhibit

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