2. Immunology/Inflammation
  3. SphK
  4. Opaganib hydrochloride

Opaganib hydrochloride  (Synonyms: ABC294640 hydrochloride)

Cat. No.: HY-16015A
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Opaganib (ABC294640) hydrochloride is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM.

For research use only. We do not sell to patients.

Opaganib hydrochloride Chemical Structure

Opaganib hydrochloride Chemical Structure

CAS No. : 1185157-59-8

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Opaganib hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Arch Med Res. 2018 Jul;49(5):335-341.  [Abstract]

    Inhibition of SphK2 by si-RNA (si-SphK2) and ABC294640 (ABC) decrease phosphorylation and acetylation of STAT3 . Also, both si-RNA and ABC294640 reverse IL-6 induced increasing phosphorylation and acetylation of STAT3.

    Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3824-3836.  [Abstract]

    NRK-49F cells are treated with TGF-β1 for the indicated time. The levels of p-STAT3, p-AKT, p-GSK3α, and p-GSK3β expression are detected in comparison with the levels of total STAT3, AKT, GSK3α, GSK3β, and with GAPDH as the loading control.

    Opaganib hydrochloride purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Mar 29;7(13):16663-75.  [Abstract]

    The western blot demonstrates the effect of ABC294640 (25 μM) for 24 h in the presence and absence of MG132 (10 μM) on Des1 expression. Actin is used a protein loading control.

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Opaganib1185157-59-8ABC294640ABC 294640ABC-294640SphKSphingosine kinaseInhibitorinhibitorinhibit

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