2. MAPK/ERK Pathway
  3. p38 MAPK
  4. Org 48762-0

Org 48762-0  (Synonyms: UR13870)

Cat. No.: HY-114221 Purity: 99.99%
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Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice.

For research use only. We do not sell to patients.

Org 48762-0 Chemical Structure

Org 48762-0 Chemical Structure

CAS No. : 755753-89-0

Size Price Stock Quantity
1 mg USD 280 In-stock
5 mg USD 700 In-stock
10 mg USD 980 In-stock
25 mg USD 1520 In-stock
50 mg USD 1980 In-stock
100 mg USD 2550 In-stock
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Based on 1 publication(s) in Google Scholar

Org 48762-0 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice[1].

Molecular Weight

398.41

Formula

C24H16F2N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1N=C2C(C(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)C(C5=CC=C(F)C=C5)=N2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (251.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5100 mL 12.5499 mL 25.0998 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5100 mL 12.5499 mL 25.0998 mL 62.7494 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL 12.5499 mL
10 mM 0.2510 mL 1.2550 mL 2.5100 mL 6.2749 mL
15 mM 0.1673 mL 0.8367 mL 1.6733 mL 4.1833 mL
20 mM 0.1255 mL 0.6275 mL 1.2550 mL 3.1375 mL
25 mM 0.1004 mL 0.5020 mL 1.0040 mL 2.5100 mL
30 mM 0.0837 mL 0.4183 mL 0.8367 mL 2.0916 mL
40 mM 0.0627 mL 0.3137 mL 0.6275 mL 1.5687 mL
50 mM 0.0502 mL 0.2510 mL 0.5020 mL 1.2550 mL
60 mM 0.0418 mL 0.2092 mL 0.4183 mL 1.0458 mL
80 mM 0.0314 mL 0.1569 mL 0.3137 mL 0.7844 mL
100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6275 mL
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Org 48762-0 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org 48762-0755753-89-0UR13870UR 13870UR-13870p38 MAPKInhibitorinhibitorinhibit

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