2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog Endogenous Metabolite
  4. Orotic acid-13C,15N2 monohydrate

Orotic acid-13C,15N2 monohydrate  (Synonyms: 6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate)

Cat. No.: HY-N0157S1 Purity: 99.93%
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Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].

For research use only. We do not sell to patients.

Orotic acid-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub> monohydrate Chemical Structure

Orotic acid-13C,15N2 monohydrate Chemical Structure

CAS No. : 1346602-15-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Orotic acid-13C,15N2 monohydrate:

Orotic acid-13C,15N2 monohydrate Related Antibodies

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Description

Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Orotic acid-13C,15N2 monohydrate Related Antibodies
Molecular Weight

177.09

Formula

C413CH615N2O5
CAS No.
Unlabeled CAS

50887-69-9
Appearance

Solid

Color

White to light yellow

SMILES

OC(C1=CC([15NH][13C]([15NH]1)=O)=O)=O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (310.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6468 mL 28.2342 mL 56.4685 mL
5 mM 1.1294 mL 5.6468 mL 11.2937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6468 mL 28.2342 mL 56.4685 mL 141.1712 mL
5 mM 1.1294 mL 5.6468 mL 11.2937 mL 28.2342 mL
10 mM 0.5647 mL 2.8234 mL 5.6468 mL 14.1171 mL
15 mM 0.3765 mL 1.8823 mL 3.7646 mL 9.4114 mL
20 mM 0.2823 mL 1.4117 mL 2.8234 mL 7.0586 mL
25 mM 0.2259 mL 1.1294 mL 2.2587 mL 5.6468 mL
30 mM 0.1882 mL 0.9411 mL 1.8823 mL 4.7057 mL
40 mM 0.1412 mL 0.7059 mL 1.4117 mL 3.5293 mL
50 mM 0.1129 mL 0.5647 mL 1.1294 mL 2.8234 mL
60 mM 0.0941 mL 0.4706 mL 0.9411 mL 2.3529 mL
80 mM 0.0706 mL 0.3529 mL 0.7059 mL 1.7646 mL
100 mM 0.0565 mL 0.2823 mL 0.5647 mL 1.4117 mL
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Orotic acid-13C,15N2 monohydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orotic acid-13C,15N21346602-15-06-Carboxyuracil-13C,15N2Vitamin B13-13C,15N2Nucleoside Antimetabolite/AnalogEndogenous MetaboliteInhibitorinhibitorinhibit

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