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OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD).

For research use only. We do not sell to patients.

OX01914 Chemical Structure

OX01914 Chemical Structure

CAS No. : 49676-35-9

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OX01914 Related Antibodies

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Description

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD)[1].

In Vitro

OX01914 (0.1, 10, 40, 50 µM; 24 h) upregulates utrophin mRNA in LUmdx and (30 µM; 24 h) H2K mdx myoblasts[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OX01914 Related Antibodies

Western Blot Analysis[1]

Cell Line: LUmdx and H2K mdx myoblasts
Concentration: 0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
Incubation Time: 24 h
Result: Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.

Western Blot Analysis[1]

Cell Line: Human DMD cells
Concentration: 1, 3, 30 µM
Incubation Time: 24 h
Result: Increased utrophin protein levels by approximately 3-fold.
Molecular Weight

290.32

Formula

C17H14N4O
CAS No.
SMILES

O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OX01914 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX0191449676-35-9OX 01914OX-01914Othersduchenne muscular dystrophyDMDutrophin proteinLUmdx myoblastsH2K mdx myoblastsDMD cellsInhibitorinhibitorinhibit

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