Oxaline

Cat. No.: HY-N8287: FAQs
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Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase.

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Oxaline Chemical Structure

CAS No. : 55623-37-5

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Description	Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase^[1]^[2].
Molecular Weight	447.49
Formula	C₂₄H₂₅N₅O₄
CAS No.	55623-37-5
SMILES	O=C1N[C@@]23N(OC)C4=C(C=CC=C4)[C@]2(C(C)(C)C=C)C=C(OC)C(N3/C1=C/C5=CN=CN5)=O
Structure Classification	Alkaloids Other Alkaloids
Initial Source	Microorganisms Penicillium oxalicum
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (277 KB) Handling Instructions (2659 KB)
References	[1]. Nagel D W, et al. X-Ray structure of oxaline: a novel alkaloid from Penicillium oxalicum. Journal of the Chemical Society. Chemical Communications. 1974 (24): 1021-1022. [2]. Koizumi Y, et al. Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization. Biochim Biophys Acta. 2004 Jul 23;1693(1):47-55. [Content Brief]

Oxaline Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxaline55623-37-5Microtubule/TubulinPenicillium oxalicumalkaloidtubulinJurkat cellsM phaseInhibitorinhibitorinhibit

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Oxaline

Oxaline Related Antibodies

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