Oxybutynin-d₁₁ chloride

Name: Oxybutynin-d 11 chloride
Brand: MedChemExpress
SKU: HY-B0267AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0267AS Purity: 97.39%: FAQs
Data Sheet SDS COA Handling Instructions

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Oxybutynin-d₁₁ (chloride) is the deuterium labeled Oxybutynin chloride. Oxybutynin chloride is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM[1].

For research use only. We do not sell to patients.

Oxybutynin-d<sub>11</sub> chloride Chemical Structure

Oxybutynin-d₁₁ chloride Chemical Structure

CAS No. : 1185151-95-4

Size	Price	Stock	Quantity
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Oxybutynin-d₁₁ chloride:

Oxybutynin chloride In-stock
(R)-Oxybutynin Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

405.02

Formula

C₂₂H₂₁D₁₁ClNO₃

CAS No.

1185151-95-4

Unlabeled CAS

1508-65-2

Appearance

Solid

Color

White to off-white

SMILES

CCN(CC)CC#CCOC(C(C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H])(C2=CC=CC=C2)O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (246.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4690 mL	12.3451 mL	24.6901 mL
5 mM	0.4938 mL	2.4690 mL	4.9380 mL
10 mM	0.2469 mL	1.2345 mL	2.4690 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.39%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (124 KB) RP-HPLC (90 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Li H, The anticholinergic drug oxybutynin inhibits voltage-dependent K⁺ channels in coronary arterial smooth muscle cells. Clin Exp Pharmacol Physiol. 2019 Nov;46(11):1030-1036. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4690 mL	12.3451 mL	24.6901 mL	61.7253 mL
	5 mM	0.4938 mL	2.4690 mL	4.9380 mL	12.3451 mL
	10 mM	0.2469 mL	1.2345 mL	2.4690 mL	6.1725 mL
	15 mM	0.1646 mL	0.8230 mL	1.6460 mL	4.1150 mL
	20 mM	0.1235 mL	0.6173 mL	1.2345 mL	3.0863 mL
	25 mM	0.0988 mL	0.4938 mL	0.9876 mL	2.4690 mL
	30 mM	0.0823 mL	0.4115 mL	0.8230 mL	2.0575 mL
	40 mM	0.0617 mL	0.3086 mL	0.6173 mL	1.5431 mL
	50 mM	0.0494 mL	0.2469 mL	0.4938 mL	1.2345 mL
	60 mM	0.0412 mL	0.2058 mL	0.4115 mL	1.0288 mL
	80 mM	0.0309 mL	0.1543 mL	0.3086 mL	0.7716 mL
	100 mM	0.0247 mL	0.1235 mL	0.2469 mL	0.6173 mL