2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage
  3. P-glycoprotein CDK
  4. P-gp/CDK2-IN-1

P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor for is inhibitor for P-glycoprotein (P-gp) and for cyclin-dependent kinase-2 (CDK2). P-gp/CDK2-IN-1 inhibits the proliferation of cancer cells SW-480 and MCF-7 wit IC50 of 38.6 μM and 26.6 μM. P-gp/CDK2-IN-1 exhibits antioxidant efficacy with EC50 of 580 μM in DPPH experiment.

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P-gp/CDK2-IN-1 Chemical Structure

P-gp/CDK2-IN-1 Chemical Structure

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P-gp/CDK2-IN-1 Related Antibodies

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Description

P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor for is inhibitor for P-glycoprotein (P-gp) and for cyclin-dependent kinase-2 (CDK2). P-gp/CDK2-IN-1 inhibits the proliferation of cancer cells SW-480 and MCF-7 wit IC50 of 38.6 μM and 26.6 μM. P-gp/CDK2-IN-1 exhibits antioxidant efficacy with EC50 of 580 μM in DPPH experiment[1].

IC50 & Target

CDK2

 

Molecular Weight

417.41

Formula

C21H23NO8
SMILES

O=C(C1=C(N)OC(C=C(C)O2)=C(C2=O)C1C3=CC(OC)=C(OC)C(OC)=C3)OCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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P-gp/CDK2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp/CDK2-IN-1P-glycoproteinCDKP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Cyclin dependent kinaseSW-480MCF-7DPPHantioxidantInhibitorinhibitorinhibit

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