2. GPCR/G Protein
  3. P2Y Receptor
  4. P2Y2R/GPR17 antagonist 1

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes.

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P2Y2R/GPR17 antagonist 1 Chemical Structure

P2Y2R/GPR17 antagonist 1 Chemical Structure

CAS No. : 2395016-49-4

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P2Y2R/GPR17 antagonist 1 Related Antibodies

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Description

P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].

IC50 & Target

IC50: 1.67 µM (GPR17), 3.17 µM (P2Y2R)[1]
Molecular Weight

432.83

Formula

C19H13ClN2O6S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(C=CC=C1)Cl)NC2=CC=C(C=C2)S(=O)(OC3=CC([N+]([O-])=O)=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (288.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3104 mL 11.5519 mL 23.1038 mL
5 mM 0.4621 mL 2.3104 mL 4.6208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3104 mL 11.5519 mL 23.1038 mL 57.7594 mL
5 mM 0.4621 mL 2.3104 mL 4.6208 mL 11.5519 mL
10 mM 0.2310 mL 1.1552 mL 2.3104 mL 5.7759 mL
15 mM 0.1540 mL 0.7701 mL 1.5403 mL 3.8506 mL
20 mM 0.1155 mL 0.5776 mL 1.1552 mL 2.8880 mL
25 mM 0.0924 mL 0.4621 mL 0.9242 mL 2.3104 mL
30 mM 0.0770 mL 0.3851 mL 0.7701 mL 1.9253 mL
40 mM 0.0578 mL 0.2888 mL 0.5776 mL 1.4440 mL
50 mM 0.0462 mL 0.2310 mL 0.4621 mL 1.1552 mL
60 mM 0.0385 mL 0.1925 mL 0.3851 mL 0.9627 mL
80 mM 0.0289 mL 0.1444 mL 0.2888 mL 0.7220 mL
100 mM 0.0231 mL 0.1155 mL 0.2310 mL 0.5776 mL
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P2Y2R/GPR17 antagonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P2Y2R/GPR17 antagonist 12395016-49-4P2Y Receptorinflammatorymetabolic stabilityInhibitorinhibitorinhibit

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