2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38-α MAPK-IN-5

p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research.

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p38-α MAPK-IN-5 Chemical Structure

p38-α MAPK-IN-5 Chemical Structure

CAS No. : 1443242-46-3

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p38-α MAPK-IN-5 Related Antibodies

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

IC50 & Target[1]

p38α

0.1 nM (IC50)

p38β

0.2 nM (IC50)

p38γ

944 nM (IC50)

p38δ

4100 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
PBMC IC50
1 nM
Compound: 4e
Inhibition of LPS-stimulated TNFalpha release in human PBMC cells preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs
Inhibition of LPS-stimulated TNFalpha release in human PBMC cells preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs
[PMID: 35546685]
Molecular Weight

679.86

Formula

C37H49N11O2
CAS No.
SMILES

O=C(N[C@H]1CC[C@H](C2=C1C=CC=C2)OC(C=C3)=CN4C3=NN=C4N5[C@H](CCCC5)C)NC6=CC(C(C)(C)C)=NN6C7=CN(N=C7)CCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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p38-α MAPK-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38-α MAPK-IN-51443242-46-3p38 MAPKp38αp38 βp38γp38δRegioisomeric pyrazoleanti-inflammatory,?asthma and chronic obstructive pulmonary diseaseCOPDInhibitorinhibitorinhibit

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