2. GPCR/G Protein
  3. PACAP Receptor
  4. PA-9

PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain.

For research use only. We do not sell to patients.

PA-9 Chemical Structure

PA-9 Chemical Structure

CAS No. : 1436004-46-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 638 In-stock
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5 mg USD 580 In-stock
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Based on 1 publication(s) in Google Scholar

PA-9 Related Antibodies

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Description

PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain[1].

IC50 & Target[1]

PAC1 receptor

 

In Vitro

PA-9 (10 pM to 10 nM; 30 minutes) dose dependently inhibits PACAP-induced (1 nM) CREB phosphorylation in the CHO cells expressing PAC1 receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PA-9 Related Antibodies
In Vivo

PA-9 (100 pmol; co-injection with PACAP) attenuates the development of PACAP-induced (100 pmol/5 μL; intrathecal injection) aversive responses of mice[1].
PA-9 (100 pmol; co-injection with PACAP) significantly blocks the induction of PACAP-induced (100 pmol) mechanical allodynia[1].
PA-9 (100 pmol/5 μl; single intrathecal injection alone) does not induce aversive responses and mechanical allodynia of mice[1].
PA-9 is well accommodated in the subpocket formed by L80, F81, I83, G91, V92, P107, A112, and C113 of the PAC1 receptor, precipitating in hydrophobic interactions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (6 weeks old at the start of experiments; intrathecal injection 100 pmol/5 μL PACAP)[1]
Dosage: intrathecal injection, co-injection with PACAP.
Administration: 100 pmol/5 μL
Result: Attenuated the development of PACAP-induced aversive responses.
Blocked the induction of PACAP-induced mechanical allodynia.
Molecular Weight

338.36

Formula

C17H18N6O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C(C1)CN(C2=NNC3=C2C=CC=C3)C1=O)NCCC4=CN=CN4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (738.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9554 mL 14.7772 mL 29.5543 mL
5 mM 0.5911 mL 2.9554 mL 5.9109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9554 mL 14.7772 mL 29.5543 mL 73.8858 mL
5 mM 0.5911 mL 2.9554 mL 5.9109 mL 14.7772 mL
10 mM 0.2955 mL 1.4777 mL 2.9554 mL 7.3886 mL
15 mM 0.1970 mL 0.9851 mL 1.9703 mL 4.9257 mL
20 mM 0.1478 mL 0.7389 mL 1.4777 mL 3.6943 mL
25 mM 0.1182 mL 0.5911 mL 1.1822 mL 2.9554 mL
30 mM 0.0985 mL 0.4926 mL 0.9851 mL 2.4629 mL
40 mM 0.0739 mL 0.3694 mL 0.7389 mL 1.8471 mL
50 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.4777 mL
60 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2314 mL
80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9236 mL
100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7389 mL
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PA-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PA-91436004-46-4PA9PA 9PACAP ReceptorPituitary adenylyl cyclase activating polypeptide receptormiceinflammatory painneuropathic painCHO cellsPACAPInhibitorinhibitorinhibit

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