2. Apoptosis
  3. Transferrin Receptor
  4. Pabinafusp alfa

Pabinafusp alfa  (Synonyms: JR-141)

Cat. No.: HY-P99797 Purity: 97.49%
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Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.

For research use only. We do not sell to patients.

CAS No. : 2140211-48-7

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Description

Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Fusion Protein
IC50 & Target

Transferrin receptor[1]
In Vivo

Pabinafusp alfa (0.1-2 mg/kg; i.v.; once weekly for 36 weeks) dose-dependently prevents neurohistopathological changes and ameliorates neurological defects in a mouse model of MPS II[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model of MPS II[1]
Dosage: 0.1 mg/kg, 0.5 mg/kg, and 2 mg/kg
Administration: Intravenous injection; once weekly for 36 weeks
Result: Dose-dependently decreases the level of heparan sulfate (HS) in the brain and cerebrospinal fluid (CSF), as well as decreasing the substrate concentrations.
Recovered spontaneous alterations in a dose-dependent manner, indicating an impaired working memory prevented.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Pabinafusp alfa]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
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Pabinafusp alfa Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pabinafusp alfa2140211-48-7JR-141JR141JR 141Transferrin ReceptorTfRCD71Inhibitorinhibitorinhibit

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