2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Palvanil

Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.

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Palvanil Chemical Structure

Palvanil Chemical Structure

CAS No. : 69693-13-6

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Based on 1 publication(s) in Google Scholar

Palvanil Related Antibodies

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Description

Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[1][2].

Cellular Effect
Cell Line Type Value Description References
EFM-19 IC50
1 μM
Compound: 3
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
MCF7 IC50
2.2 μM
Compound: 3
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
T47D IC50
1.6 μM
Compound: 3
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
[PMID: 33508189]
In Vitro

Palvanil (0.1-1000 nM; 0-300 min) leads to calcium increasment in HEK-293 intracellular[1].
Palvanil (1-10 nM; 5 min) treatment desensitizes TRPV1 to the effect of Capsaicin significantly[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palvanil Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK-293 cells
Concentration: 0.1, 0.5, 1, 5, 10, 50, 100 and 1000 nM
Incubation Time: 0-300 min
Result: Produced a dose-dependent increase in intracellular calcium with a EC50 of 0.65 nM.

Cell Viability Assay[1]

Cell Line: HEK-293-TPRV1 cells
Concentration: 1-10 nM
Incubation Time: 5 min
Result: Desensitized TRPV1 to the effect of Capsaicin significantly (IC50=0.81 nM).
In Vivo

Palvanil (subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect[2].
Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation[2].
Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia in spared nerve injury (SNI) mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice[2]
Dosage: 1 or 10 mg/kg
Administration: Subcutaneous injection; 1 or 10 mg/kg; once
Result: Led to a slight and short lasting hypothermic effect, produced late hyperthermia.
Animal Model: Female BALB/C mice[2]
Dosage: 100 μL (15 nM) per mouse
Administration: Intraperitoneal injection; 100 μL (15 nM) per mouse; once
Result: Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s).
Animal Model: Male CD-1 mice received formalin[2]
Dosage: 0.5, 0.75, and 1 mg/kg
Administration: Intravenous injection; 0.5, 0.75, and 1 mg/kg; once
Result: Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner.
Animal Model: Male C57BL/6J mice with acute inflammation induced by Carrageenan[2]
Dosage: 2.5 mg/kg
Administration: Intravenous injection; 2.5 mg/kg; once
Result: Reduced the volume of the oedema in the ipsilateral hind paw (64%).
Animal Model: Male CD-1 mice[2]
Dosage: 0.5 and 1 mg/kg
Administration: Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days
Result: Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner.
Molecular Weight

391.59

Formula

C24H41NO3
CAS No.
SMILES

CCCCCCCCCCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Palvanil Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palvanil69693-13-6TRP ChannelTransient receptor potential channelsanti-nociceptiveanti-inflammationHEK-293Inhibitorinhibitorinhibit

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