PAMP-12 (unmodified)

Name: PAMP-12 (unmodified)
Brand: MedChemExpress
SKU: HY-P3419
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3419 Purity: 98.75%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC₅₀=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PAMP-12 (unmodified) Chemical Structure

CAS No. : 929905-12-4

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PAMP-12 (unmodified):

PAMP-12 (unmodified) (TFA) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

1619.91

Formula

C₇₇H₁₁₈N₂₄O₁₅

CAS No.

929905-12-4

Appearance

Solid

Color

White to off-white

Sequence

Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg

Sequence Shortening

FRKKWNKWALSR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (61.73 mM; Need ultrasonic)

DMSO : 50 mg/mL (30.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6173 mL	3.0866 mL	6.1732 mL
5 mM	0.1235 mL	0.6173 mL	1.2346 mL
10 mM	0.0617 mL	0.3087 mL	0.6173 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.75%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (110 KB) MS (222 KB)

Handling Instructions (2659 KB)

References

[1]. Kamohara M, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 2005;330(4):1146-1152. [Content Brief]

[2]. Chen E, et al. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target. Gastroenterology. 2021;160(5):1709-1724. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	0.6173 mL	3.0866 mL	6.1732 mL	15.4330 mL
	5 mM	0.1235 mL	0.6173 mL	1.2346 mL	3.0866 mL
	10 mM	0.0617 mL	0.3087 mL	0.6173 mL	1.5433 mL
	15 mM	0.0412 mL	0.2058 mL	0.4115 mL	1.0289 mL
	20 mM	0.0309 mL	0.1543 mL	0.3087 mL	0.7716 mL
	25 mM	0.0247 mL	0.1235 mL	0.2469 mL	0.6173 mL
	30 mM	0.0206 mL	0.1029 mL	0.2058 mL	0.5144 mL
H₂O	40 mM	0.0154 mL	0.0772 mL	0.1543 mL	0.3858 mL
	50 mM	0.0123 mL	0.0617 mL	0.1235 mL	0.3087 mL
	60 mM	0.0103 mL	0.0514 mL	0.1029 mL	0.2572 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.