2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. PAMP-12 (unmodified)

PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells.

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Custom Peptide Synthesis

PAMP-12 (unmodified) Chemical Structure

PAMP-12 (unmodified) Chemical Structure

CAS No. : 929905-12-4

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5 mg USD 200 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PAMP-12 (unmodified):

PAMP-12 (unmodified) Related Antibodies

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Description

PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells[1].

Molecular Weight

1619.91

Formula

C77H118N24O15
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg
Sequence Shortening

FRKKWNKWALSR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (61.73 mM; Need ultrasonic)

DMSO : 50 mg/mL (30.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6173 mL 3.0866 mL 6.1732 mL
5 mM 0.1235 mL 0.6173 mL 1.2346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.75%

COA (249 KB) RP-HPLC (110 KB) MS (222 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.6173 mL 3.0866 mL 6.1732 mL 15.4330 mL
5 mM 0.1235 mL 0.6173 mL 1.2346 mL 3.0866 mL
10 mM 0.0617 mL 0.3087 mL 0.6173 mL 1.5433 mL
15 mM 0.0412 mL 0.2058 mL 0.4115 mL 1.0289 mL
20 mM 0.0309 mL 0.1543 mL 0.3087 mL 0.7716 mL
25 mM 0.0247 mL 0.1235 mL 0.2469 mL 0.6173 mL
30 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5144 mL
H2O 40 mM 0.0154 mL 0.0772 mL 0.1543 mL 0.3858 mL
50 mM 0.0123 mL 0.0617 mL 0.1235 mL 0.3087 mL
60 mM 0.0103 mL 0.0514 mL 0.1029 mL 0.2572 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PAMP-12 (unmodified) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAMP-12 (unmodified)929905-12-4Mas-related G-protein-coupled Receptor (MRGPR)endogenous peptidehypotensioncatecholamine secretionsympathetic nerveadrenal chromaffin cellsInhibitorinhibitorinhibit

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