2. Others Neuronal Signaling Autophagy
  3. Isotope-Labeled Compounds Serotonin Transporter Autophagy
  4. Paroxetine-d4 hydrochloride

Paroxetine-d4 hydrochloride  (Synonyms: BRL29060-d4 hydrochloride; BRL29060A-d4)

Cat. No.: HY-B0492S1 Purity: 99.16%
COA Handling Instructions

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Paroxetine-d4 (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3].

For research use only. We do not sell to patients.

Paroxetine-d<sub>4</sub> hydrochloride Chemical Structure

Paroxetine-d4 hydrochloride Chemical Structure

CAS No. : 2714485-95-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Paroxetine-d4 hydrochloride:

Paroxetine-d4 hydrochloride Related Antibodies

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Description

Paroxetine-d4 (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Paroxetine-d4 hydrochloride Related Antibodies
Molecular Weight

369.85

Formula

C19H17D4ClFNO3
CAS No.
Unlabeled CAS

78246-49-8
Appearance

Solid

Color

White to off-white

SMILES

FC(C([2H])=C1[2H])=C([2H])C([2H])=C1[C@H](CCNC2)[C@@H]2COC3=CC=C(OCO4)C4=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (270.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (270.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 5 mg/mL (13.52 mM; Need ultrasonic)

H2O : 5 mg/mL (13.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7038 mL 13.5190 mL 27.0380 mL
5 mM 0.5408 mL 2.7038 mL 5.4076 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 2.7038 mL 13.5190 mL 27.0380 mL 67.5950 mL
5 mM 0.5408 mL 2.7038 mL 5.4076 mL 13.5190 mL
10 mM 0.2704 mL 1.3519 mL 2.7038 mL 6.7595 mL
DMSO / DMSO 15 mM 0.1803 mL 0.9013 mL 1.8025 mL 4.5063 mL
20 mM 0.1352 mL 0.6759 mL 1.3519 mL 3.3797 mL
25 mM 0.1082 mL 0.5408 mL 1.0815 mL 2.7038 mL
30 mM 0.0901 mL 0.4506 mL 0.9013 mL 2.2532 mL
40 mM 0.0676 mL 0.3380 mL 0.6759 mL 1.6899 mL
50 mM 0.0541 mL 0.2704 mL 0.5408 mL 1.3519 mL
60 mM 0.0451 mL 0.2253 mL 0.4506 mL 1.1266 mL
80 mM 0.0338 mL 0.1690 mL 0.3380 mL 0.8449 mL
100 mM 0.0270 mL 0.1352 mL 0.2704 mL 0.6759 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Paroxetine-d4 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paroxetine-d42714485-95-5BRL29060-d4BRL29060A-d4Isotope-Labeled CompoundsSerotonin TransporterAutophagy5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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