2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. PARP CDK Apoptosis
  4. PARP-1/2-IN-2

PARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor.

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PARP-1/2-IN-2 Chemical Structure

PARP-1/2-IN-2 Chemical Structure

CAS No. : 3052304-23-8

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PARP-1/2-IN-2 Related Antibodies

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Description

PARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor[1].

Molecular Weight

610.41

Formula

C25H23IN8O3
CAS No.
SMILES

NC(C1=CC=CC2=C1N=C(NC(C3=CC(C(N4CCC(NC5=NC=C(I)C=N5)CC4)=O)=CC=C3)=O)N2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PARP-1/2-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP-1/2-IN-23052304-23-8PARPCDKApoptosispoly ADP ribose polymerase Cyclin dependent kinasecancerbreast cancerTNBCMDA-MB-231MDA-MB-468Inhibitorinhibitorinhibit

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