1. Anti-infection
  2. HIV
  3. Patentiflorin A

Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains.

For research use only. We do not sell to patients.

Patentiflorin A Chemical Structure

Patentiflorin A Chemical Structure

CAS No. : 857050-63-6

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Description

Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains[1].

IC50 & Target

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.99 μM
Compound: 2
Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay
[PMID: 22119124]
K562 IC50
1.43 μM
Compound: 2
Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay
[PMID: 22119124]
K562 IC50
16.14 μM
Compound: 2
Cytotoxicity against adriamycin-selected multi drug-resistant human K562 cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against adriamycin-selected multi drug-resistant human K562 cells after 72 hrs by sulforhodamine B and MTT assay
[PMID: 22119124]
KB IC50
0.093 μM
Compound: 2
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay
[PMID: 22119124]
KB IC50
0.573 μM
Compound: 2
Cytotoxicity against vincristine-selected multi drug-resistant human KB cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against vincristine-selected multi drug-resistant human KB cells after 72 hrs by sulforhodamine B and MTT assay
[PMID: 22119124]
MCF7 IC50
0.44 μM
Compound: 2
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay
[PMID: 22119124]
PBMC CC50
75 μM
Compound: 1, Natural
Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
[PMID: 28613071]
PBMC CC50
75 μM
Compound: 1, synthesized
Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay
[PMID: 28613071]
In Vitro

Patentiflorin A shows inhibition activity with IC50 values of 32, 31, 30, 32, 108, 61 and 47 nM against Bal: M-Tropic, 89.6: Dual-Tropic, SF162: M-Tropic, Lav.04: T-Tropic, HIV-1LAV, HIV-11617-1 and HIV-1N119, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

526.49

Formula

C27H26O11

CAS No.
SMILES

O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C)O)O)O)=C2CO1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Patentiflorin A
Cat. No.:
HY-N10430
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