Patentiflorin A

Cat. No.: HY-N10430: FAQs
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Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains.

For research use only. We do not sell to patients.

Patentiflorin A Chemical Structure

CAS No. : 857050-63-6

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HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Patentiflorin A is a potent, broadspectrum HIV-1 inhibitor. Patentiflorin A also inhibits HIV drug-resistant strains^[1].

IC₅₀ & Target

HIV-1

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.99 μM Compound: 2	Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
K562	IC₅₀	1.43 μM Compound: 2	Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
K562	IC₅₀	16.14 μM Compound: 2	Cytotoxicity against adriamycin-selected multi drug-resistant human K562 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against adriamycin-selected multi drug-resistant human K562 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
KB	IC₅₀	0.093 μM Compound: 2	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
KB	IC₅₀	0.573 μM Compound: 2	Cytotoxicity against vincristine-selected multi drug-resistant human KB cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against vincristine-selected multi drug-resistant human KB cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
MCF7	IC₅₀	0.44 μM Compound: 2	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay	[PMID: 22119124]
PBMC	CC₅₀	75 μM Compound: 1, Natural	Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 28613071]
PBMC	CC₅₀	75 μM Compound: 1, synthesized	Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay Cytotoxicity against human PBMC after 48 hrs by CellTiter 96 AQueous one solution cell proliferation assay	[PMID: 28613071]

In Vitro

Patentiflorin A shows inhibition activity with IC₅₀ values of 32, 31, 30, 32, 108, 61 and 47 nM against Bal: M-Tropic, 89.6: Dual-Tropic, SF162: M-Tropic, Lav.04: T-Tropic, HIV-1_LAV, HIV-1_1617-1 and HIV-1_N119, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

526.49

Formula

C₂₇H₂₆O₁₁

CAS No.

857050-63-6

SMILES

O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C)O)O)O)=C2CO1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang HJ, et al. Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa. J Nat Prod. 2017 Jun 23;80(6):1798-1807. [Content Brief]

Patentiflorin A Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patentiflorin A857050-63-6HIVHuman immunodeficiency virusJusticia gendarussaInhibitorinhibitorinhibit

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