2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. EGFR Akt ERK PARP Survivin
  4. Patritumab

Patritumab  (Synonyms: Human Anti-ERBB3 Recombinant Antibody)

Cat. No.: HY-P99275 Purity: 98.95%
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Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors.

For research use only. We do not sell to patients.

CAS No. : 1262787-83-6

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Based on 1 publication(s) in Google Scholar

Patritumab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Patritumab

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors[1].

Isotype

Human IgG1(K214R) kappa
Recommend Isotype Controls
Species

Human
In Vitro

Patritumab targets to the extracellular domain (ECD) of HER3 and (10 μg/mL; 5 d) induces DiFi-HRG4 cells apoptosis[1].
Patritumab (10 μg/mL; 6 h) markedly inhibits the phosphorylation of HER3 and AKT, without affecting that of ERK, in DiFi-HRG4 cells[1].
Patritumab (10 μg/mL; 48 h) also induces the cleavage of PARP accompanied with both up-regulation of BIM and down-regulation of survivin expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Patritumab Related Antibodies

Western Blot Analysis[1]

Cell Line: DiFi-HRG cells
Concentration: 10 μg/mL
Incubation Time: 6 hours
Result: Inhibited the phosphorylation of HER3 and AKT as well as down-regulated survivin expression.
In Vivo

Patritumab (1 mg/mouse; i.p.; twice a week for 4 weeks) combines with 1 mg Cetuximab and restores Cetuximab sensitivity in DiFi-HRG tumor xenografts model in mice[1].
Heregulin produced by colorectal cancer tumors harboring wild-type KRAS induces Cetuximab resistance, and that combination therapy with cetuximab and patritumab overcomes such resistance in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (BALB/c; 5-6 weeks old) with DiFi-Mock1 or DiFi-HRG4 (s.c.)[1]
Dosage: 1 mg/body
Administration: Intraperitoneal injection; twice a week for 4 weeks
Result: Individual Patritumab treatment had little effect on the growth of tumors formed by either cell line.
Combination of Cetuximab and Patritumab induced substantial regression of DiFi-HRG4 xenografts.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Patritumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Patritumab on AHC2 biosensor, can bind HER3 Protein, Human (HEK293, His, HY-P72625) with an affinity constant of 1.804E-09 M as determined in BLI assay.
Purity & Documentation

Purity: 98.95%

SDS (251 KB)

COA (231 KB) SDS-PAGE (164 KB) SEC-HPLC (108 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Patritumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patritumab1262787-83-6Human Anti-ERBB3 Recombinant AntibodyEGFRAktERKPARPSurvivinEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasespoly ADP ribose polymeraseneutralizing monoclonal antibodyDiFi-HRG tumor xenografts modelpancreaticnon-small cell lung cancercolorectal cancerInhibitorinhibitorinhibit

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