2. Epigenetics
  3. Epigenetic Reader Domain
  4. PBRM1-BD2-IN-7

PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC50 value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer.

For research use only. We do not sell to patients.

PBRM1-BD2-IN-7 Chemical Structure

PBRM1-BD2-IN-7 Chemical Structure

CAS No. : 2819989-68-7

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Based on 1 publication(s) in Google Scholar

PBRM1-BD2-IN-7 Related Antibodies

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Description

PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC50 value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.29 μM (PBRM1-BD2)[1].
Cellular Effect
Cell Line Type Value Description References
LNCaP IC50
2 μM
Compound: 26
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay
[PMID: 36227159]
PC-3 IC50
2 μM
Compound: 26
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 6 days with compound replacement for every 48 hrs by celltiter-glo assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 6 days with compound replacement for every 48 hrs by celltiter-glo assay
[PMID: 36227159]
In Vitro

PBRM1-BD2-IN-7 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1].
PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with IC50 value of 0.29 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PBRM1-BD2-IN-7 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human prostate cell lines LNCaP, PC3, and RWPE-1
Concentration: 0, 0.1, 1, and 10 μM
Incubation Time: 5 days
Result: Inhibited LNCaP growth at higher concentrations.
Molecular Weight

286.76

Formula

C16H15ClN2O
CAS No.
SMILES

O=C1NC(C2=C(C)C=CC=C2C)NC3=C1C(Cl)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PBRM1-BD2-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBRM1-BD2-IN-72819989-68-7Epigenetic Reader Domainpolybromo-1 (PBRM1)bromodomainbinding affinityinhibitorycancerInhibitorinhibitorinhibit

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