PC-Biotin-PEG4-NHS carbonate

Name: PC-Biotin-PEG4-NHS carbonate
Brand: MedChemExpress
SKU: HY-140135
Rating: 4.5 (1 reviews)

Cat. No.: HY-140135 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

PC-Biotin-PEG4-NHS carbonate Chemical Structure

CAS No. : 2055198-03-1

Size	Price	Stock	Quantity
5 mg	USD 62	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 99	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 197	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 325	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 528	Get quote	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

810.87

Formula

C₃₅H₅₀N₆O₁₄S

CAS No.

2055198-03-1

Appearance

Solid

Color

White to off-white

SMILES

O=C1N[C@]2(CS[C@H]([C@]2(N1)[H])CCCCC(NCCOCCOCCOCCOCCC(NCC3=CC(C(OC(ON4C(CCC4=O)=O)=O)C)=C([N+]([O-])=O)C=C3)=O)=O)[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (61.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2332 mL	6.1662 mL	12.3324 mL
5 mM	0.2466 mL	1.2332 mL	2.4665 mL
10 mM	0.1233 mL	0.6166 mL	1.2332 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (245 KB) HNMR (122 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2332 mL	6.1662 mL	12.3324 mL	30.8311 mL
	5 mM	0.2466 mL	1.2332 mL	2.4665 mL	6.1662 mL
	10 mM	0.1233 mL	0.6166 mL	1.2332 mL	3.0831 mL
	15 mM	0.0822 mL	0.4111 mL	0.8222 mL	2.0554 mL
	20 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.5416 mL
	25 mM	0.0493 mL	0.2466 mL	0.4933 mL	1.2332 mL
	30 mM	0.0411 mL	0.2055 mL	0.4111 mL	1.0277 mL
	40 mM	0.0308 mL	0.1542 mL	0.3083 mL	0.7708 mL
	50 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.6166 mL
	60 mM	0.0206 mL	0.1028 mL	0.2055 mL	0.5139 mL