PC DBCO-PEG3-biotin

Cat. No.: HY-140136: FAQs
Data Sheet Handling Instructions

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PC DBCO-PEG3-biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PC DBCO-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

PC DBCO-PEG3-biotin Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

PC DBCO-PEG3-biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. PC DBCO-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1002.14

Formula

C₅₀H₆₃N₇O₁₃S

SMILES

[H][C@@]1(N2)CS[C@@H]([C@](NC2=O)1[H])CCCCC(NCCOCCOCCOCCNC(CCCOC(C=C3[N+]([O-])=O)=C(C=C3C(C)OC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)OC)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]