PC Mal-NHS carbonate ester

Name: PC Mal-NHS carbonate ester
Brand: MedChemExpress
SKU: HY-140140
Rating: 4.5 (1 reviews)

Cat. No.: HY-140140 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

PC Mal-NHS carbonate ester Chemical Structure

CAS No. : 1408057-91-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

562.48

Formula

C₂₄H₂₆N₄O₁₂

CAS No.

1408057-91-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(CCC1=O)=O)OC(C2=CC(OC)=C(OCCCC(NCCN3C(C=CC3=O)=O)=O)C=C2[N+]([O-])=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (177.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7778 mL	8.8892 mL	17.7784 mL
5 mM	0.3556 mL	1.7778 mL	3.5557 mL
10 mM	0.1778 mL	0.8889 mL	1.7778 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (248 KB) HNMR (216 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7778 mL	8.8892 mL	17.7784 mL	44.4460 mL
	5 mM	0.3556 mL	1.7778 mL	3.5557 mL	8.8892 mL
	10 mM	0.1778 mL	0.8889 mL	1.7778 mL	4.4446 mL
	15 mM	0.1185 mL	0.5926 mL	1.1852 mL	2.9631 mL
	20 mM	0.0889 mL	0.4445 mL	0.8889 mL	2.2223 mL
	25 mM	0.0711 mL	0.3556 mL	0.7111 mL	1.7778 mL
	30 mM	0.0593 mL	0.2963 mL	0.5926 mL	1.4815 mL
	40 mM	0.0444 mL	0.2222 mL	0.4445 mL	1.1112 mL
	50 mM	0.0356 mL	0.1778 mL	0.3556 mL	0.8889 mL
	60 mM	0.0296 mL	0.1482 mL	0.2963 mL	0.7408 mL
	80 mM	0.0222 mL	0.1111 mL	0.2222 mL	0.5556 mL
	100 mM	0.0178 mL	0.0889 mL	0.1778 mL	0.4445 mL