2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE1-IN-8

PDE1-IN-8 (Compound 3f) is the inhibitor for PDE1 with an IC50 of 11 nM. PDE1-IN-8 inhibits cAMP and cGMP signaling pathway, inhibits the differentiation and proliferation of cells into myofibroblast, and exhibits anti-fibrotic efficacy in Bleomycin (HY-17565)-induced rat pulmonary fibrosis model.

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PDE1-IN-8 Chemical Structure

PDE1-IN-8 Chemical Structure

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PDE1-IN-8 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

PDE1-IN-8 (Compound 3f) is the inhibitor for PDE1 with an IC50 of 11 nM. PDE1-IN-8 inhibits cAMP and cGMP signaling pathway, inhibits the differentiation and proliferation of cells into myofibroblast, and exhibits anti-fibrotic efficacy in Bleomycin (HY-17565)-induced rat pulmonary fibrosis model[1].

IC50 & Target

PDE1C

11 nM (IC50)

PDE1A

263 nM (IC50)

PDE1B

357 nM (IC50)

PDE5A

681 nM (IC50)

PDE2A

1820 nM (IC50)

PDE7A

2093 nM (IC50)

PDE10A

2394 nM (IC50)

PDE4D

3006 nM (IC50)

PDE8A

3729 nM (IC50)

PDE9A

4617 nM (IC50)

PDE3A

5164 nM (IC50)

Molecular Weight

408.32

Formula

C17H11Cl2N3OS2
SMILES

ClC1=CC=CC(C(C)SC2=NC(C3=CC=C(S3)Cl)=C(C(N2)=O)C#N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PDE1-IN-8 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE1-IN-8Phosphodiesterase (PDE)MRC-5anti-fibroticSprague-Dawley ratInhibitorinhibitorinhibit

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PDE1-IN-8
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HY-169963
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