2. PI3K/Akt/mTOR
  3. PDK-1
  4. PDK1-IN-2

PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1, thereby inhibiting the kinase activity and downstream signaling of PDK1. PDK1-IN-2 can be used for cell survival and proliferation in cancer.

For research use only. We do not sell to patients.

PDK1-IN-2 Chemical Structure

PDK1-IN-2 Chemical Structure

CAS No. : 1643958-85-3

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1 mg USD 350 In-stock
5 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

PDK1-IN-2 Related Antibodies

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Description

PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1, thereby inhibiting the kinase activity and downstream signaling of PDK1. PDK1-IN-2 can be used for cell survival and proliferation in cancer[1].

Molecular Weight

380.89

Formula

C15H9ClN2O2S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=NC2=C(S1)C=C(Cl)C=C2)(C3=CSC4=C3C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (10.50 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6254 mL 13.1271 mL 26.2543 mL
5 mM 0.5251 mL 2.6254 mL 5.2509 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6254 mL 13.1271 mL 26.2543 mL 65.6357 mL
5 mM 0.5251 mL 2.6254 mL 5.2509 mL 13.1271 mL
10 mM 0.2625 mL 1.3127 mL 2.6254 mL 6.5636 mL
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PDK1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDK1-IN-21643958-85-3PDK-13-Phosphoinositide-dependent protein kinase 1PDKPI3K/AKT signaling pathwaycell survival and proliferationPIF pocketInhibitorinhibitorinhibit

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