2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. PE 22-28

PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PE 22-28 Chemical Structure

PE 22-28 Chemical Structure

CAS No. : 1801959-12-5

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Based on 1 publication(s) in Google Scholar

PE 22-28 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].

IC50 & Target

IC50: 0.12 nM (TREK-1)[1]
In Vitro

PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PE 22-28 Related Antibodies
In Vivo

PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naïve male C57Bl/6J mice[1]
Dosage: 3.0µg/kg
Administration: Intraperitoneal
Result: Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.
Molecular Weight

773.88

Formula

C35H55N11O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Val-Ser-Trp-Gly-Leu-Arg
Sequence Shortening

GVSWGLR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (64.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 21.7 mg/mL (28.04 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2922 mL 6.4609 mL 12.9219 mL
5 mM 0.2584 mL 1.2922 mL 2.5844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.2922 mL 6.4609 mL 12.9219 mL 32.3047 mL
5 mM 0.2584 mL 1.2922 mL 2.5844 mL 6.4609 mL
10 mM 0.1292 mL 0.6461 mL 1.2922 mL 3.2305 mL
15 mM 0.0861 mL 0.4307 mL 0.8615 mL 2.1536 mL
20 mM 0.0646 mL 0.3230 mL 0.6461 mL 1.6152 mL
25 mM 0.0517 mL 0.2584 mL 0.5169 mL 1.2922 mL
DMSO 30 mM 0.0431 mL 0.2154 mL 0.4307 mL 1.0768 mL
40 mM 0.0323 mL 0.1615 mL 0.3230 mL 0.8076 mL
50 mM 0.0258 mL 0.1292 mL 0.2584 mL 0.6461 mL
60 mM 0.0215 mL 0.1077 mL 0.2154 mL 0.5384 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PE 22-28 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PE 22-281801959-12-5Potassium ChannelKcsATREK-1amino-acid peptidechemical modificationsubstitutiondepressionInhibitorinhibitorinhibit

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