Peanut procyanidin A

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Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis.

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Peanut procyanidin A Chemical Structure

CAS No. : 1802175-67-2

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Description	Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from H₂O₂-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis^[1]^[2].
Molecular Weight	864.76
Formula	C₄₅H₃₆O₁₈
CAS No.	1802175-67-2
SMILES	O[C@H]([C@H](C(C=C1)=CC(O)=C1O)O2)[C@H](C(C2=CC(O)=C3)=C3O)C4=C(O)C(O)=CC5=C4O[C@@](C6=CC=C(O)C(O)=C6)(O7)[C@H](O)[C@H]5C(C(O[C@@H]8C(C=C9)=CC(O)=C9O)=C%10C[C@@H]8O)=C7C=C%10O
Structure Classification	Phenols Polyphenols
Initial Source	Plants Leguminosae Arachis hypogaea L.
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (276 KB) Handling Instructions (2659 KB)
References	[1]. Yan F, et al. Protective effect of procyanidin A-type dimers against H2O2-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway. Life Sci. 2021 Feb 1;266:118908. [Content Brief] [2]. Huang B, et al. The underlying mechanism of A-type procyanidins from peanut skin on DSS-induced ulcerative colitis mice by regulating gut microbiota and metabolism. J Food Biochem. 2022 Jul;46(7):e14103. [Content Brief]