Penciclovir sodium (Synonyms: VSA 671 sodium; BRL 39123A; BRL 39123D)

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Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC₅₀ values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse.

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Penciclovir sodium Chemical Structure

CAS No. : 97845-62-0

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Other In-stock Forms of Penciclovir sodium:

Penciclovir

Other Forms of Penciclovir sodium:

Penciclovir In-stock

1 Publications Citing Use of MCE Penciclovir sodium

•Microchem J. 2021, 106587.

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References
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Description

IC₅₀ & Target^[1]

HSV-1

0.5 μg/mL (EC₅₀)

HSV-2

0.8 μg/mL (EC₅₀)

In Vitro

Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC₅₀s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively^[1].
Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells
Concentration:	0-100 µg/ml
Incubation Time:
Result:	Showed no-toxic with IC₅₀s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.

In Vivo

Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Three-week-old female Balb/c mice^[2]
Dosage:	100 mg/kg
Administration:	S.c.; daily for 5 days
Result:	Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.

Clinical Trial

Molecular Weight

275.24

Formula

C₁₀H₁₄N₅NaO₃

CAS No.

97845-62-0

SMILES

OCC(CO[Na])CCN1C2=C(C(NC(N)=N2)=O)N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1): 3-11.

[2]. de la Fuente R, et al. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18(1):77-89. [Content Brief]

Penciclovir sodium Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penciclovir97845-62-0VSA 671 BRL 39123A BRL 39123DVSA671VSA-671HSVHerpes simplex virusanti-herpesvirusno-toxicmortalityInhibitorinhibitorinhibit

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