2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Pepinh-TRIF TFA

Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction.

For research use only. We do not sell to patients.

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Pepinh-TRIF TFA Chemical Structure

Pepinh-TRIF TFA Chemical Structure

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Based on 4 publication(s) in Google Scholar

Pepinh-TRIF TFA Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction[1].

IC50 & Target

TLRs

 

In Vitro

Pepinh-TRIF (40 μM, 6 hours) blocks the expression and production of IL-33 stimulated by polyI:C or flagellin, and also greatly suppresses the stimulated IκB-α phosphorylation and degradation in HCECs[1].
Pepinh-TRIF (40 μM, 6 hours) suppresses NF-κB activation with p65 protein nuclear translocation [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pepinh-TRIF TFA Related Antibodies

Western Blot Analysis[1]

Cell Line: HCECs
Concentration: 40 μM
Incubation Time: 6 hours
Result: Blocked NF-κB activation with p65 nuclear translocation.
Molecular Weight

3875.54 (free base)

Formula

C177H273N55O40S2.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Phe-Cys-Glu-Glu-Phe-Gln-Val-Pro-Gly-Arg-Gly-Glu-Leu-His-NH2
Sequence Shortening

RQIKIWFQNRRMKWKKFCEEFQVPGRGELH-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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Pepinh-TRIF TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pepinh-TRIFToll-like Receptor (TLR)peptideTRIFTIR-domain-containingadapter-inducinginterferon-βTLRtoll-likereceptorInhibitorinhibitorinhibit

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