2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. PF-06456384

PF-06456384 is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 has the potential for formalin pain model research.

For research use only. We do not sell to patients.

PF-06456384 Chemical Structure

PF-06456384 Chemical Structure

CAS No. : 1834610-73-9

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Description

PF-06456384 is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 has the potential for formalin pain model research[1].

IC50 & Target[1]

Nav1.7

0.01 nM (IC50)

Molecular Weight

719.80

Formula

C35H32F3N7O3S2
CAS No.
SMILES

N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-06456384 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-064563841834610-73-9PF06456384PF 06456384Sodium ChannelNa channelsNa+ channelsNaV1.7formalin painInhibitorinhibitorinhibit

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