2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. PF-06456384 trihydrochloride

PF-06456384 trihydrochloride is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research.

For research use only. We do not sell to patients.

PF-06456384 trihydrochloride Chemical Structure

PF-06456384 trihydrochloride Chemical Structure

CAS No. : 1834610-75-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 164 In-stock
Solution
10 mM * 1 mL in DMSO USD 164 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 180 In-stock
25 mg USD 380 In-stock
50 mg USD 670 In-stock
100 mg USD 1160 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of PF-06456384 trihydrochloride:

PF-06456384 trihydrochloride Related Antibodies

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Description

PF-06456384 trihydrochloride is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research[1].

IC50 & Target[1]

Nav1.7

0.01 nM (IC50)

Molecular Weight

829.18

Formula

C35H35Cl3F3N7O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (150.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2060 mL 6.0301 mL 12.0601 mL
5 mM 0.2412 mL 1.2060 mL 2.4120 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2060 mL 6.0301 mL 12.0601 mL 30.1503 mL
5 mM 0.2412 mL 1.2060 mL 2.4120 mL 6.0301 mL
10 mM 0.1206 mL 0.6030 mL 1.2060 mL 3.0150 mL
15 mM 0.0804 mL 0.4020 mL 0.8040 mL 2.0100 mL
20 mM 0.0603 mL 0.3015 mL 0.6030 mL 1.5075 mL
25 mM 0.0482 mL 0.2412 mL 0.4824 mL 1.2060 mL
30 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0050 mL
40 mM 0.0302 mL 0.1508 mL 0.3015 mL 0.7538 mL
50 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.6030 mL
60 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5025 mL
80 mM 0.0151 mL 0.0754 mL 0.1508 mL 0.3769 mL
100 mM 0.0121 mL 0.0603 mL 0.1206 mL 0.3015 mL
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PF-06456384 trihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-06456384 trihydrochloride1834610-75-1Sodium ChannelNa channelsNa+ channelsNaV1.7formalin painInhibitorinhibitorinhibit

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