PF-06456384 trihydrochloride

Cat. No.: HY-118952A Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PF-06456384 trihydrochloride is a highly potent and selective Na_V1.7 inhibitor with an IC₅₀ of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research.

For research use only. We do not sell to patients.

PF-06456384 trihydrochloride Chemical Structure

CAS No. : 1834610-75-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 164	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 164	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 670	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1160	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PF-06456384 trihydrochloride:

PF-06456384 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

PF-06456384 trihydrochloride is a highly potent and selective Na_V1.7 inhibitor with an IC₅₀ of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research^[1].

IC₅₀ & Target^[1]

Na_v1.7

0.01 nM (IC₅₀)

Molecular Weight

829.18

Formula

C₃₅H₃₅Cl₃F₃N₇O₃S₂

CAS No.

1834610-75-1

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (150.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2060 mL	6.0301 mL	12.0601 mL
5 mM	0.2412 mL	1.2060 mL	2.4120 mL
10 mM	0.1206 mL	0.6030 mL	1.2060 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (253 KB) HNMR (333 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. R Ian Storer, et al. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2060 mL	6.0301 mL	12.0601 mL	30.1503 mL
	5 mM	0.2412 mL	1.2060 mL	2.4120 mL	6.0301 mL
	10 mM	0.1206 mL	0.6030 mL	1.2060 mL	3.0150 mL
	15 mM	0.0804 mL	0.4020 mL	0.8040 mL	2.0100 mL
	20 mM	0.0603 mL	0.3015 mL	0.6030 mL	1.5075 mL
	25 mM	0.0482 mL	0.2412 mL	0.4824 mL	1.2060 mL
	30 mM	0.0402 mL	0.2010 mL	0.4020 mL	1.0050 mL
	40 mM	0.0302 mL	0.1508 mL	0.3015 mL	0.7538 mL
	50 mM	0.0241 mL	0.1206 mL	0.2412 mL	0.6030 mL
	60 mM	0.0201 mL	0.1005 mL	0.2010 mL	0.5025 mL
	80 mM	0.0151 mL	0.0754 mL	0.1508 mL	0.3769 mL
	100 mM	0.0121 mL	0.0603 mL	0.1206 mL	0.3015 mL