PF2562

Cat. No.: HY-120879: FAQs
Data Sheet Handling Instructions

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PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a K_i of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC₅₀ of 568 nM in HTRF assay.

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PF2562 Chemical Structure

CAS No. : 1609258-91-4

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Purity & Documentation
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Description	PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a K_i of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC₅₀ of 568 nM in HTRF assay^[1].
IC₅₀ & Target	EC50: 568 nM (human D1 cAMP)^[1] Ki: 113 nM (human D1 receptor)^[1]
In Vitro	Dopamine acts upon neurons through two families of dopamine receptors, D1-like receptors (D1Rs) and D2-like receptors (D2Rs). The D1-like receptor family consists of D1 and D5 receptors which are expressed in many regions of the brain. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. PF2562 Related Antibodies
Molecular Weight	331.37
Formula	C₁₉H₁₇N₅O
CAS No.	1609258-91-4
SMILES	CC1=CC(OC2=NC=CC3=C2C=NN3)=CC=C1C4=C(N=CN=C4C)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Jennifer Elizabeth Davoren, et al. Heteroaromatic compounds and their use as dopamine d1 ligands. US20140128374A1.

PF2562 Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF25621609258-91-4PF 2562PF-2562Dopamine ReceptorAlzheimerSchizophreniaParkinsondiseaseInhibitorinhibitorinhibit

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