2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. PF2562

PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay.

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PF2562 Chemical Structure

PF2562 Chemical Structure

CAS No. : 1609258-91-4

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PF2562 Related Antibodies

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Description

PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay[1].

IC50 & Target

EC50: 568 nM (human D1 cAMP)[1]
Ki: 113 nM (human D1 receptor)[1]
In Vitro

Dopamine acts upon neurons through two families of dopamine receptors, D1-like receptors (D1Rs) and D2-like receptors (D2Rs). The D1-like receptor family consists of D1 and D5 receptors which are expressed in many regions of the brain. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF2562 Related Antibodies
Molecular Weight

331.37

Formula

C19H17N5O
CAS No.
SMILES

CC1=CC(OC2=NC=CC3=C2C=NN3)=CC=C1C4=C(N=CN=C4C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF2562 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF25621609258-91-4PF 2562PF-2562Dopamine ReceptorAlzheimerSchizophreniaParkinsondiseaseInhibitorinhibitorinhibit

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