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  5. PGlu-3-methyl-His-Pro-NH2 TFA

PGlu-3-methyl-His-Pro-NH2 TFA  (Synonyms: A-42872 TFA)

Cat. No.: HY-107380A Purity: 99.69%
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PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole.

For research use only. We do not sell to patients.

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PGlu-3-methyl-His-Pro-NH2 TFA Chemical Structure

PGlu-3-methyl-His-Pro-NH2 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 165 In-stock
10 mg USD 265 In-stock
25 mg USD 550 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

PGlu-3-methyl-His-Pro-NH2 TFA Related Antibodies

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Description

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole[1][2].

In Vitro

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA) has a very high affinity for the TRH receptor in the CNS. PGlu-3-methyl-His-Pro-NH2 TFA is more potent in eliciting behavioral effects as well as being more potent in the release of both growth hormone and thyroid stimulating hormone[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PGlu-3-methyl-His-Pro-NH2 TFA Related Antibodies
In Vivo

PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA) (300 μg/kg; i.v.) elicits a 80 % increase in cerebral blood flow. Even a minute dose of PGlu-3-methyl-His-Pro-NH2 TFA (625 ng kg-1) causes an increase in cerebral blood flow[1].
The addition of 3% terpene in combination with 47% ethanol increases the penetration of PGlu-3-methyl-His-Pro-NH2 TFA (5 mg/ml; transdermal administration; 30 minutes)[2].
Topical application of PGlu-3-methyl-His-Pro-NH2 TFA induces an increase in TSH serum concentration from 0.32 ng/ml to 22.9 ng/ml, respectively, after 30 min. The addition of Terpene and Ethanol in combination with TRH or PGlu-3-methyl-His-Pro-NH2 TFA, increases the TSH release to 43 and 48.4 ng/ml, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (weighing 296–356 g)[2]
Dosage: 5 mg/ml
Administration: Transdermal administration; 30 minutes
Result: Increased in TSH-response in the presence of enhancers (3% Cineole and 47% Ethanol) as compared to peptide without enhancers.
Molecular Weight

490.43

Formula

C19H25F3N6O6
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (509.76 mM; Need ultrasonic)

DMSO : 100 mg/mL (203.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0390 mL 10.1951 mL 20.3903 mL
5 mM 0.4078 mL 2.0390 mL 4.0781 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (203.90 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.0390 mL 10.1951 mL 20.3903 mL 50.9757 mL
5 mM 0.4078 mL 2.0390 mL 4.0781 mL 10.1951 mL
10 mM 0.2039 mL 1.0195 mL 2.0390 mL 5.0976 mL
15 mM 0.1359 mL 0.6797 mL 1.3594 mL 3.3984 mL
20 mM 0.1020 mL 0.5098 mL 1.0195 mL 2.5488 mL
25 mM 0.0816 mL 0.4078 mL 0.8156 mL 2.0390 mL
30 mM 0.0680 mL 0.3398 mL 0.6797 mL 1.6992 mL
40 mM 0.0510 mL 0.2549 mL 0.5098 mL 1.2744 mL
50 mM 0.0408 mL 0.2039 mL 0.4078 mL 1.0195 mL
60 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8496 mL
80 mM 0.0255 mL 0.1274 mL 0.2549 mL 0.6372 mL
100 mM 0.0204 mL 0.1020 mL 0.2039 mL 0.5098 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PGlu-3-methyl-His-Pro-NH2 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PGlu-3-methyl-His-Pro-NH2A-42872A42872A 42872OthersanaloguesTRHreceptorTSHpermeabilityenhancerspenetrationInhibitorinhibitorinhibit

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