2. Metabolic Enzyme/Protease
  3. Liposome
  4. Phospholipid PL1

Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity.

For research use only. We do not sell to patients.

Phospholipid PL1 Chemical Structure

Phospholipid PL1 Chemical Structure

CAS No. : 2274812-94-9

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Phospholipid PL1 Related Antibodies

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Description

Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity[1].

In Vivo

Phospholipid PL1 (10 µg mRNA/mouse; i.t.; 6 times every other day; for 60 d) improves the immunotherapy with an anti-CD137 Ab and antitumor activity with an anti-OX40 Ab in tumor models with better results obtained in the B16F10 melanoma model than the A20 lymphoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 melanoma mouse model and A20 lymphoma mouse model (C57BL/6 mice)[1]
Dosage: Administration of PL1-CD137 + anti-CD137 Ab; PL1-CD137 (10 µg mRNA/mouse), and anti-CD137 Ab (16 µg/mouse)
Administration: Intratumoral injection; 6 times every other day; 60 days
Result: Dramatically decreased the tumor growth rate by 5-fold (18 days after inoculation), and increased the overall survival time in B16F10 melanoma model.
Resulted in a 2-fold decrease in the tumor growth rate (18d after inoculation) in A20 lymphoma model, without significant extension in the overall survival time.
Animal Model: B16F10 melanoma mouse model and CT26 colon carcinoma mouse model (C57BL/6 mice)[1]
Dosage: Administration of PL1-OX40 + anti-OX40 Ab; PL1-OX40 (10 µg mRNA/mouse), and anti-OX40 Ab (8 µg/mouse)
Administration: Intratumoral injection; 6 times every other day; 60 days
Result: Significantly decreased the tumor growth and prolonged survival in comparison to treatment with PBS and PL1-OX40 + anti-OX40 Ab in both tumor models.
Molecular Weight

1073.59

Formula

C61H121N2O10P
CAS No.
SMILES

O=C(CCCCCCCCN(CCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)CCCOP(OCC)(OCC)=O)OC(CCCCC)CC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phospholipid PL1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phospholipid PL12274812-94-9Phospholipid PL 1Phospholipid PL-1Liposomebiomimetic phospholipidcostimulatory receptorCD137OX40B16F10 melanoma modelA20 lymphoma modelCT26 colon carcinoma modelInhibitorinhibitorinhibit

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