Photoclick cholesterol

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Photoclick cholesterol is a sterol lipid cholesterol analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group. Photoclick cholesterol has the ability to photoaffinity label the mitochondrial outer membrane transport protein (TSPO) and is able to specifically bind cholesterol to TSPO. However, using excessive amounts of Photoclick cholesterol will reduce the photolabeling of total mitochondrial proteins and TSPO.

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Photoclick cholesterol Chemical Structure

CAS No. : 1485490-47-8

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Description	Photoclick cholesterol is a sterol lipid cholesterol analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group. Photoclick cholesterol has the ability to photoaffinity label the mitochondrial outer membrane transport protein (TSPO) and is able to specifically bind cholesterol to TSPO. However, using excessive amounts of Photoclick cholesterol will reduce the photolabeling of total mitochondrial proteins and TSPO^[1].
Molecular Weight	482.70
Formula	C₃₀H₄₆N₂O₃
CAS No.	1485490-47-8
SMILES	C[C@]12[C@@](C[C@H](CC2)O)([H])C3(N=N3)C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@H](C)CCC(OCCCCC#C)=O)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Georges E, et al. Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue[J]. The journal of biochemistry, 2021, 170(2): 239-243. [Content Brief]